Sodium selenite attenuated cisplatin-induced toxicity in rats: role of electrolytes homeostasis.

Sodium selenite (1 mg/kg body weight, ip) for 10 consecutive days treatment showed marked increase in intra-erythrocytes K+ and plasma Na+ level while slight increase in Na+ K+ ATPase level. No mortality was observed at this dose of sodium selenite. However, sodium selenite pretreatment partially restored the Na+ K+ ATPase and intra-erythorcytes and plasma sodium level, while completely restored the intra-erythrocytes K+ and plasma Mg2+ level. No change was observed in plasma Ca2+ level. Thus sodium selenite successively attenuated the Cisplatin-induced electrolytes alterations and toxicity by exerting the stress response of sodium.